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33 Publications visible to you, out of a total of 33
Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial

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Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies. The objectives of this trial were to compare the efficacy and … safety of curcumin with fluoxetine in patients with major depressive disorder (MDD). Herein, 60 patients diagnosed with MDD were randomized in a 1:1:1 ratio for six weeks observer-masked treatment with fluoxetine (20 mg) and curcumin (1000 mg) individually or their combination. The primary efficacy variable was response rates according to Hamilton Depression Rating Scale, 17-item version (HAM-D17 ). The secondary efficacy variable was the mean change in HAM-D17 score after six weeks. We observed that curcumin was well tolerated by all the patients. The proportion of responders as measured by the HAM-D17 scale was higher in the combination group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups; however, these data were not statistically significant (P = 0.58). Interestingly, the mean change in HAM-D17 score at the end of six weeks was comparable in all three groups (P = 0.77). This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders. Copyright © 2013 John Wiley & Sons, Ltd.

Authors: Jayesh Sanmukhani, Vimal Satodia, Jaladhi Trivedi, Tejas Patel, Deepak Tiwari, Bharat Panchal, Ajay Goel, Chandra Bhanu Tripathi

Date Published: 9th Jul 2013

Publication Type: Not specified

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

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Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the … cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or signal transduction. Integrated models that are able to span and interconnect these layers are, by contrast, rare as their construction and analysis face multiple challenges. Such methods, however, would represent extremely useful tools to understand cell behaviour, with application in distinct fields of biological and medical research. In particular, they could be useful tools to study genotype-phenotype mappings, and the way they are affected by specific conditions or perturbations. Here, we review existing computational approaches that integrate signalling, gene regulation and/or metabolism. We describe existing challenges, available methods and point at potentially useful strategies.

Authors: Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha, Julio Saez-Rodriguez

Date Published: 4th Jun 2013

Publication Type: Not specified

The Taverna workflow suite: designing and executing workflows of Web Services on the desktop, web or in the cloud

Abstract

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Authors: K. Wolstencroft, R. Haines, D. Fellows, A. Williams, D. Withers, S. Owen, S. Soiland-Reyes, I. Dunlop, A. Nenadic, P. Fisher, J. Bhagat, K. Belhajjame, F. Bacall, A. Hardisty, A. Nieva de la Hidalga, M. P. Balcazar Vargas, S. Sufi, C. Goble

Date Published: 2nd May 2013

Publication Type: Not specified

The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels

Abstract (Expand)

The African annual fish Nothobranchius furzeri has over recent years been established as a model species for ageing-related studies. This is mainly based on its exceptionally short lifespan and the … presence of typical characteristics of vertebrate ageing. To substantiate its role as an alternative vertebrate ageing model, a transcript catalogue is needed, which can serve e.g. as basis for identifying ageing-related genes.

Authors: Andreas Petzold, Kathrin Reichwald, Marco Groth, Stefan Taudien, Nils Hartmann, Steffen Priebe, Dmitry Shagin, Christoph Englert, Matthias Platzer

Date Published: 16th Mar 2013

Publication Type: Not specified

Biggest challenges in bioinformatics

Abstract (Expand)

The third Heidelberg Unseminars in Bioinformatics (HUB) was held on 18th October 2012, at Heidelberg University, Germany. HUB brought together around 40 bioinformaticians from academia and industry to … discuss the 'Biggest Challenges in Bioinformatics' in a 'World Cafe' style event.

Authors: J. C. Fuller, P. Khoueiry, H. Dinkel, K. Forslund, A. Stamatakis, J. Barry, A. Budd, T. G. Soldatos, K. Linssen, A. M. Rajput

Date Published: 15th Mar 2013

Publication Type: Not specified

Stealthy annotation of experimental biology by spreadsheets

Abstract

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Authors: Firstname Lastname, Firstname Lastname, Matthew Horridge, Simon Jupp, Firstname Lastname, Firstname Lastname, Firstname Lastname, Wolfgang Mueller, Robert Stevens, Firstname Lastname

Date Published: 1st Feb 2013

Publication Type: Not specified

A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development

Abstract

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Editor:

Date Published: 2013

Publication Type: Not specified

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