Publications

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33 Publications visible to you, out of a total of 33

Abstract

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Author: I N Golovistikov

Date Published: 11th Aug 1975

Publication Type: Not specified

Abstract

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Authors: I. V. Berezin, B. M. Kershengol'ts, N. N. Ugarova

Date Published: 11th Aug 1975

Publication Type: Not specified

Abstract

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Authors: Y Yokoyama, T Kono, M Aoki

Date Published: 10th Jun 1975

Publication Type: Not specified

Abstract

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Authors: A B Makar, K E McMartin, M Palese, T R Tephly

Date Published: 1st Jun 1975

Publication Type: Not specified

Abstract (Expand)

UNLABELLED: Oscillations are widely distributed in nature and synchronization of oscillators has been described at the cellular level (e.g. heart cells) and at the population level (e.g. fireflies). Yeast glycolysis is the best known oscillatory system, although it has been studied almost exclusively at the population level (i.e. limited to observations of average behaviour in synchronized cultures). We studied individual yeast cells that were positioned with optical tweezers in a microfluidic chamber to determine the precise conditions for autonomous glycolytic oscillations. Hopf bifurcation points were determined experimentally in individual cells as a function of glucose and cyanide concentrations. The experiments were analyzed in a detailed mathematical model and could be interpreted in terms of an oscillatory manifold in a three-dimensional state-space; crossing the boundaries of the manifold coincides with the onset of oscillations and positioning along the longitudinal axis of the volume sets the period. The oscillatory manifold could be approximated by allosteric control values of phosphofructokinase for ATP and AMP. DATABASE: The mathematical models described here have been submitted to the JWS Online Cellular Systems Modelling Database and can be accessed at http://jjj.mib.ac.uk/webMathematica/UItester.jsp?modelName=gustavsson5. [Database section added 14 May 2014 after original online publication].

Authors: A. K. Gustavsson, D. D. van Niekerk, C. B. Adiels, B. Kooi, M. Goksor, J. L. Snoep

Date Published: No date defined

Publication Type: Not specified

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