Glucose metabolism in Plasmodium falciparum trophozoites

The investigation entails the construction and validation of a detailed mathematical model for glycolysis of the malaria parasite Plasmodium falciparum in the blood stage trophozoite form.

DOI: 10.5072/seek.investigation.12.2

Created at: 22nd Oct 2015 at 08:47

Contents

Model validation

This study includes the experimental data for model validation and the model predictions of that data set.

GLC incubation

No description specified

5mM GLC runout data.

No description specified

  • Validation-5mMGLCrunout-penkler2.xlsx

Kinetic model for incubation

Glycolytic model for Plasmodium falciparum; closed system

  • penkler2.dat
  • penkler2.nb
  • penkler2.sedx

Validation experiments

SOP for the determination of external metabolites (Glc, Pyr, Gly, Lac) in intact trophozoite incubations, and for the determination of intracellular metabolite concentrations.

  • Validation SOP.docx
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Created: 22nd Oct 2015 at 08:47

Last updated: 22nd Oct 2015 at 08:48

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