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Submitter
Guest3
Project
SysMO DB3
Programme
Dummy programme3
Organism
Callimico goeldii1
Modelling analysis type
Metabolism1
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No description specified
Creator: Jacky Snoep
Submitter: Guest
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Not specified
DownloadTargeting persistent tubercule bacilli has become an important challenge in the development of anti-tuberculous drugs. As the glyoxylate bypass is essential for persistent bacilli, interference with it holds the potential for designing new antibacterial drugs. We have developed kinetic models of the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of inhibition of various enzymes in the M. tuberculosis model.
