Objective 1

RTG2978, “Understanding and Exploiting Adaptation to Therapy in Gastrointestinal Cancer,” is a joint doctoral training program of the University Medical Center Goettingen (UMG) and Hannover Medical School (MHH), embedded in the Comprehensive Cancer Center Lower Saxony (CCC-N). The program addresses one of the central challenges in gastrointestinal oncology that is, the ability of liver (HCC), biliary tract (BTC), pancreatic (PDAC), and colorectal cancers (CRC) to rapidly adapt to therapeutic ...

SP1: Understanding and exploiting molecular and cellular reprogramming in response to EZH2 inhibition in PDAC

In SP1, the Hauschild and Hessmann groups will combine their expertise in bioinformatics, machine learning, as well as advanced AI methods and Gl cancer modeling and epigenetic targeting, respectively, to dissect the molecular underpinnings and the therapeutic consequences of EZH2-inhibition (EZH2i)-induced adaptation in PDAC. In the canonical Polycomb-Repressor-Complex 2 pathway, EZH2 ...