GRK2978

RTG2978, “Understanding and Exploiting Adaptation to Therapy in Gastrointestinal Cancer,” is a joint doctoral training program of the University Medical Center Goettingen (UMG) and Hannover Medical School (MHH), embedded in the Comprehensive Cancer Center Lower Saxony (CCC-N). The program addresses one of the central challenges in gastrointestinal oncology that is, the ability of liver (HCC), biliary tract (BTC), pancreatic (PDAC), and colorectal cancers (CRC) to rapidly adapt to therapeutic stress, which drives treatment resistance and poor patient outcomes. RTG2978 brings together clinicians, basic researchers, and computational scientists to investigate both tumor-intrinsic mechanisms and adaptations within the microenvironment and at systemic levels. Its an interdisciplinary research program, structured into 12 interconnected projects, aims not only to elucidate the molecular underpinnings of therapy-induced adaptation but also to exploit these insights to develop novel treatment strategies.