Projects

SP1: Understanding and exploiting molecular and cellular reprogramming in response to EZH2 inhibition in PDAC

In SP1, the Hauschild and Hessmann groups will combine their expertise in bioinformatics, machine learning, as well as advanced AI methods and Gl cancer modeling and epigenetic targeting, respectively, to dissect the molecular underpinnings and the therapeutic consequences of EZH2-inhibition (EZH2i)-induced adaptation in PDAC. In the canonical Polycomb-Repressor-Complex 2 pathway, EZH2 ...