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70
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Glycolytic model for Plasmodium falciparum; closed system
Creator: Stuart Owen
Submitter: Stuart Owen
Model type: Not specified
Model format: Not specified
Environment: Not specified
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Targeting persistent tubercule bacilli has become an important challenge in the development of anti-tuberculous drugs. As the glyoxylate bypass is essential for persistent bacilli, interference with it holds the potential for designing new antibacterial drugs. We have developed kinetic models of the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of inhibition of various enzymes in the M. tuberculosis model.
